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Detta är en lista över 1988 års förstaplaceringar på Billboard Hot 100.

Datum	Låt	Artist
2 januari	"Faith"	George Michael
9 januari	"So Emotional"	Whitney Houston
16 januari	"Got My Mind Set on You"	George Harrison
23 januari	"The Way You Make Me Feel"	Michael Jackson
30 januari	"Need You Tonight"	INXS
6 februari	"Could've Been"	Tiffany
13 februari	"Could've Been"	Tiffany
20 februari	"Seasons Change"	Exposé
27 februari	"Father Figure"	George Michael
5 mars	"Father Figure"	George Michael
12 mars	"Never Gonna Give You Up"	Rick Astley
19 mars	"Never Gonna Give You Up"	Rick Astley
26 mars	"Man in the Mirror"	Michael Jackson
2 april	"Man in the Mirror"	Michael Jackson
9 april	"Get Outta My Dreams, Get Into My Car"	Billy Ocean
16 april	"Get Outta My Dreams, Get Into My Car"	Billy Ocean
23 april	"Where Do Broken Hearts Go"	Whitney Houston
30 april	"Where Do Broken Hearts Go"	Whitney Houston
7 maj	"Wishing Well"	Terence Trent D'Arby
14 maj	"Anything for You"	Gloria Estefan and Miami Sound Machine
21 maj	"Anything for You"	Gloria Estefan and Miami Sound Machine
28 maj	"One More Try"	George Michael
4 juni	"One More Try"	George Michael
11 juni	"One More Try"	George Michael
18 juni	"Together Forever"	Rick Astley
25 juni	"Foolish Beat"	Debbie Gibson
2 juli	"Dirty Diana"	Michael Jackson
9 juli	"The Flame"	Cheap Trick
16 juli	"The Flame"	Cheap Trick
23 juli	"Hold on to the Nights"	Richard Marx
30 juli	"Roll With It"	Steve Winwood
6 augusti	"Roll With It"	Steve Winwood
13 augusti	"Roll With It"	Steve Winwood
20 augusti	"Roll With It"	Steve Winwood
27 augusti	"Monkey"	George Michael
3 september	"Monkey"	George Michael
10 september	"Sweet Child o' Mine"	Guns N' Roses
17 september	"Sweet Child o' Mine"	Guns N' Roses
24 september	"Don't Worry, Be Happy"	Bobby McFerrin
1 oktober	"Don't Worry, Be Happy"	Bobby McFerrin
8 oktober	"Love Bites"	Def Leppard
15 oktober	"Red Red Wine"	UB40
22 oktober	"Groovy Kind of Love"	Phil Collins
29 oktober	"Groovy Kind of Love"	Phil Collins
5 november	"Kokomo"	The Beach Boys
12 november	"Wild, Wild West"	The Escape Club
19 november	"Bad Medicine"	Bon Jovi
26 november	"Bad Medicine"	Bon Jovi
3 december	"Baby, I Love Your Way / Freebird Medley"	Will to Power
10 december	"Look Away"	Chicago
17 december	"Look Away"	Chicago
24 december	"Every Rose Has Its Thorn"	Poison
31 december	"Every Rose Has Its Thorn"	Poison